Dung d\u1ecbch ti\u00eam truy\u1ec1n t\u0129nh m\u1ea1ch c\u00f3 ch\u1ee9a calci<\/em><\/strong> (bao g\u1ed3m calci clorid, ringer lactat, dung d\u1ecbch nu\u00f4i d\u01b0\u1ee1ng t\u0129nh m\u1ea1ch c\u00f3 ch\u1ee9a calci)<\/td>\n| H\u00ecnh th\u00e0nh t\u1ee7a calci – ceftriaxon t\u1ea1i m\u00f4 ph\u1ed5i v\u00e0 th\u1eadn khi d\u00f9ng \u0111\u1ed3ng th\u1eddi \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch \u1edf tr\u1ebb s\u01a1 sinh<\/td>\n | T\u1ea1o k\u1ebft t\u1ee7a t\u1ea1i ph\u1ed5i v\u00e0 th\u1eadn, c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn t\u1eed vong \u1edf tr\u1ebb s\u01a1 sinh<\/td>\n | 1. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi \u1edf tr\u1ebb s\u01a1 sinh (< 28 ng\u00e0y tu\u1ed5i).<\/p>\n 2. \u1ede c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng kh\u00e1c, kh\u00f4ng tr\u1ed9n l\u1eabn calci v\u00e0 ceftriaxon trong c\u00f9ng 1 \u0111\u01b0\u1eddng truy\u1ec1n, d\u00f9ng 2 thu\u1ed1c theo 2 \u0111\u01b0\u1eddng truy\u1ec1n t\u1ea1i 2 v\u1ecb tr\u00ed kh\u00e1c nhau ho\u1eb7c d\u00f9ng l\u1ea7n l\u01b0\u1ee3t t\u1eebng thu\u1ed1c sau khi tr\u00e1ng r\u1eeda \u0111\u01b0\u1eddng truy\u1ec1n b\u1eb1ng dung m\u00f4i t\u01b0\u01a1ng h\u1ee3p.<\/td>\n<\/tr>\n | \n| 7<\/td>\n | Ciprofloxacin<\/td>\n | Domperidon<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 8<\/td>\n | Clarithromycin<\/td>\n | Methylergometrin<\/td>\n | Clarithromycin \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh l\u00e0m chuy\u1ec3n h\u00f3a methylergometrin<\/td>\n | T\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a methylergometrin trong huy\u1ebft thanh, t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh (n\u00f4n, bu\u1ed3n n\u00f4n, ho\u1ea1i t\u1eed \u0111\u1ea7u chi, thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 do co th\u1eaft m\u1ea1ch…)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 9<\/td>\n | Clarithromycin<\/td>\n | Domperidon<\/td>\n | Clarithromycin \u1ee9c ch\u1ebf CYP3A4 l\u00e0m chuy\u1ec3n h\u00f3a domperidon<\/td>\n | T\u0103ng n\u1ed3ng \u0111\u1ed9 domperidon trong huy\u1ebft thanh, t\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 10<\/td>\n | Clarithromycin<\/td>\n | Fluconazol<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | 1. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng QT k\u00e9o d\u00e0i do di truy\u1ec1n ho\u1eb7c m\u1eafc ph\u1ea3i.<\/p>\n 2. Tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n kh\u00e1c, t\u1ed1t nh\u1ea5t n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p c\u00e1c thu\u1ed1c n\u00e0y. Trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft ph\u1ed1i h\u1ee3p, c\u1ea7n \u0111\u00e1nh gi\u00e1 c\u1ea9n th\u1eadn nguy c\u01a1\/l\u1ee3i \u00edch v\u00e0 l\u01b0\u1ee3ng gi\u00e1 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tr\u00ean t\u1eebng b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i (h\u1ea1 kali m\u00e1u, h\u1ea1 magie m\u00e1u, h\u1ea1 calci m\u00e1u), nh\u1ecbp tim ch\u1eadm, n\u1eef gi\u1edbi tr\u01b0\u1edbc khi quy\u1ebft \u0111\u1ecbnh k\u00ea \u0111\u01a1n.<\/td>\n<\/tr>\n |
\n| 11<\/td>\n | Dextromethorphan<\/td>\n | Linezolid<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng serotonin<\/td>\n | T\u0103ng nguy c\u01a1 h\u1ed9i ch\u1ee9ng serotonin (s\u1ed1t cao, r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c, t\u0103ng ph\u1ea3n x\u1ea1, m\u1ea5t ph\u1ed1i h\u1ee3p, rung gi\u1eadt c\u01a1, c\u1ee9ng c\u01a1, co gi\u1eadt, nh\u1ecbp tim nhanh, t\u0103ng huy\u1ebft \u00e1p, t\u0103ng th\u00e2n nhi\u1ec7t, v\u00e3 m\u1ed3 h\u00f4i, \u1ea3o gi\u00e1c, k\u00edch \u0111\u1ed9ng ho\u1eb7c b\u1ed3n ch\u1ed3n\u2026)<\/td>\n | 1. C\u1ed1 g\u1eafng tr\u00e1nh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi linezolid v\u00e0 dextromethorphan. T\u1ed1t nh\u1ea5t c\u00e1c thu\u1ed1c n\u00e0y n\u00ean s\u1eed d\u1ee5ng c\u00e1ch nhau 2 tu\u1ea7n. C\u00e2n nh\u1eafc thay \u0111\u1ed5i sang c\u00e1c thu\u1ed1c nh\u00f3m kh\u00e1c c\u00f3 c\u00f9ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 \u00edt c\u00f3 nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c h\u01a1n. Trong tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c s\u1eed d\u1ee5ng opioid, c\u00f3 th\u1ec3 \u0111\u1ed5i sang c\u00e1c opioid kh\u00e1c kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf thu h\u1ed3i serotonin (codein).<\/p>\n 2. Trong h\u1ee3p kh\u00f4ng th\u1ec3 tr\u00ec ho\u00e3n \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c 2 tu\u1ea7n, b\u1eaft bu\u1ed9c s\u1eed d\u1ee5ng d\u00e0i ng\u00e0y ho\u1eb7c kh\u1ea9n c\u1ea5p b\u1eb1ng linezolid v\u00e0 kh\u00f4ng c\u00f3 thu\u1ed1c kh\u00e1c thay th\u1ebf, c\u00e2n b\u1eb1ng l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 x\u1ea3y ra h\u1ed9i ch\u1ee9ng serotonin. N\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1, v\u1eabn c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi nh\u01b0ng c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t trong th\u00e1ng \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi 2 thu\u1ed1c<\/td>\n<\/tr>\n |
\n| 12<\/td>\n | Diclofenac<\/td>\n | Ketorolac<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng k\u00edch \u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/td>\n | T\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a nghi\u00eam tr\u1ecdng (s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi ketorolac v\u1edbi 1 NSAID kh\u00e1c l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a g\u1ea5p 5 l\u1ea7n so v\u1edbi ph\u1ed1i h\u1ee3p 2 NSAID kh\u00e1c)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p. C\u1ea7n \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c trong tr\u01b0\u1eddng h\u1ee3p gi\u1ea3m \u0111au h\u1eadu ph\u1eabu.<\/td>\n<\/tr>\n |
\n| 13<\/td>\n | Domperidon<\/td>\n | Propofol<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng\u00a0t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p.<\/td>\n<\/tr>\n |
\n| 14<\/td>\n | Domperidon<\/td>\n | Sevofluran<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng\u00a0t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p.<\/td>\n<\/tr>\n |
\n| 15<\/td>\n | Domperidon<\/td>\n | Levofloxacin<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 16<\/td>\n | Domperidon<\/td>\n | Ondansetron<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 17<\/td>\n | Domperidon<\/td>\n | Itraconazol<\/td>\n | Itraconazol \u1ee9c ch\u1ebf CYP3A4 l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3a c\u1ee7a domperidon<\/td>\n | T\u0103ng n\u1ed3ng \u0111\u1ed9 domperidon trong huy\u1ebft thanh, t\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 18<\/td>\n | Doxycyclin<\/td>\n | Isotretinoin<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng \u0111\u1ed9c t\u00ednh<\/td>\n | T\u0103ng nguy c\u01a1 t\u0103ng \u00e1p n\u1ed9i so\u0323 l\u00e0nh t\u00ednh (ph\u00f9 gai th\u1ecb, \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n, v\u00e0 r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 19<\/td>\n | Erythromycin<\/td>\n | Methylergometrin<\/td>\n | Erythromycin \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3a c\u1ee7a methylergometrin<\/td>\n | T\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a methylergometrin trong huy\u1ebft thanh, t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh (n\u00f4n, bu\u1ed3n n\u00f4n, ho\u1ea1i t\u1eed \u0111\u1ea7u chi, thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 do co th\u1eaft m\u1ea1ch\u2026)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 20<\/td>\n | Erythromycin<\/td>\n | Fluconazol<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng\u00a0t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | 1. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng QT k\u00e9o d\u00e0i do di truy\u1ec1n ho\u1eb7c m\u1eafc ph\u1ea3i.<\/p>\n 2. Tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n kh\u00e1c, t\u1ed1t nh\u1ea5t n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p c\u00e1c thu\u1ed1c n\u00e0y. Trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft ph\u1ed1i h\u1ee3p, c\u1ea7n \u0111\u00e1nh gi\u00e1 c\u1ea9n th\u1eadn nguy c\u01a1\/l\u1ee3i \u00edch v\u00e0 l\u01b0\u1ee3ng gi\u00e1 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tr\u00ean t\u1eebng b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i (h\u1ea1 kali m\u00e1u, h\u1ea1 magie m\u00e1u, h\u1ea1 calci m\u00e1u), nh\u1ecbp tim ch\u1eadm, n\u1eef gi\u1edbi tr\u01b0\u1edbc khi quy\u1ebft \u0111\u1ecbnh k\u00ea \u0111\u01a1n.<\/td>\n<\/tr>\n |
\n| 21<\/td>\n | Fluconazol<\/td>\n | Domperidon<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 22<\/td>\n | Fluconazol<\/td>\n | Ondansetron<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng t\u00e1c d\u1ee5ng<\/td>\n | T\u0103ng nguy c\u01a1 k\u00e9o d\u00e0i kho\u1ea3ng QT, xo\u1eafn \u0111\u1ec9nh<\/td>\n | 1. Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p \u1edf c\u00e1c b\u1ec7nh nh\u00e2n c\u00f3 h\u1ed9i ch\u1ee9ng QT k\u00e9o d\u00e0i do di truy\u1ec1n ho\u1eb7c m\u1eafc ph\u1ea3i.<\/p>\n 2. Tr\u00ean c\u00e1c \u0111\u1ed1i t\u01b0\u1ee3ng b\u1ec7nh nh\u00e2n kh\u00e1c, t\u1ed1t nh\u1ea5t n\u00ean tr\u00e1nh ph\u1ed1i h\u1ee3p c\u00e1c thu\u1ed1c n\u00e0y. Trong tr\u01b0\u1eddng h\u1ee3p c\u1ea7n thi\u1ebft ph\u1ed1i h\u1ee3p, c\u1ea7n \u0111\u00e1nh gi\u00e1 c\u1ea9n th\u1eadn nguy c\u01a1\/l\u1ee3i \u00edch v\u00e0 l\u01b0\u1ee3ng gi\u00e1 c\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1 tr\u00ean t\u1eebng b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t l\u00e0 r\u1ed1i lo\u1ea1n \u0111i\u1ec7n gi\u1ea3i (h\u1ea1 kali m\u00e1u, h\u1ea1 magie m\u00e1u, h\u1ea1 calci m\u00e1u), nh\u1ecbp tim ch\u1eadm, n\u1eef gi\u1edbi tr\u01b0\u1edbc khi quy\u1ebft \u0111\u1ecbnh k\u00ea \u0111\u01a1n.<\/td>\n<\/tr>\n |
\n| 23<\/td>\n | Ibuprofen<\/td>\n | Ketorolac<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng k\u00edch \u1ee9ng \u0111\u01b0\u1eddng ti\u00eau h\u00f3a<\/td>\n | T\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft \u0111\u01b0\u1eddng ti\u00eau h\u00f3a nghi\u00eam tr\u1ecdng (s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi ketorolac v\u1edbi 1 NSAID kh\u00e1c l\u00e0m t\u0103ng nguy c\u01a1 xu\u1ea5t huy\u1ebft ti\u00eau h\u00f3a g\u1ea5p 5 l\u1ea7n so v\u1edbi ph\u1ed1i h\u1ee3p 2 NSAID kh\u00e1c)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p. C\u1ea7n \u0111\u1eb7c bi\u1ec7t l\u01b0u \u00fd nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c trong tr\u01b0\u1eddng h\u1ee3p gi\u1ea3m \u0111au h\u1eadu ph\u1eabu.<\/td>\n<\/tr>\n |
\n| 24<\/td>\n | Isotretinoin<\/td>\n | Tetracyclin<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng \u0111\u1ed9c t\u00ednh<\/td>\n | T\u0103ng nguy c\u01a1 t\u1eb7ng \u00e1p n\u1ed9i s\u1ecd l\u00e0nh t\u00ednh (ph\u00f9 gai th\u1ecb, \u0111au \u0111\u1ea7u, bu\u1ed3n n\u00f4n v\u00e0 n\u00f4n, r\u1ed1i lo\u1ea1n th\u1ecb gi\u00e1c)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 25<\/td>\n | Itraconazol<\/td>\n | Methylergometrin<\/td>\n | Ittraconazo \u1ee9c ch\u1ebf CYP3A4 m\u1ea1nh l\u00e0m gi\u1ea3m chuy\u1ec3n h\u00f3a c\u1ee7a methylergometrin<\/td>\n | T\u0103ng n\u1ed3ng \u0111\u1ed9 c\u1ee7a methylergometrin trong huy\u1ebft thanh, t\u0103ng nguy c\u01a1 \u0111\u1ed9c t\u00ednh (n\u00f4n, bu\u1ed3n n\u00f4n, ho\u1ea1i t\u1eed \u0111\u1ea7u chi, thi\u1ebfu m\u00e1u c\u1ee5c b\u1ed9 do co th\u1eaft m\u1ea1ch)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 26<\/td>\n | Linezolid<\/td>\n | Nefopam<\/td>\n | Nefopam \u1ee9c ch\u1ebf thu h\u1ed3i noradrenanin v\u00e0 serotonin tr\u00ean h\u1ec7 th\u1ea7n kinh<\/td>\n | T\u0103ng nguy c\u01a1 k\u00edch th\u00edch th\u1ea7n kinh trung \u01b0\u1edbng (co gi\u1eadt, \u1ea3o gi\u00e1c v\u00e0 k\u00edch \u0111\u1ed9ng)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n |
\n| 27<\/td>\n | Linezolid<\/td>\n | Fentanyl<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u00e1c d\u1ee5ng serotonin<\/td>\n | T\u0103ng nguy c\u01a1 h\u1ed9i ch\u1ee9ng serotonin (s\u1ed1t cao, r\u1ed1i lo\u1ea1n nh\u1eadn th\u1ee9c, t\u0103ng ph\u1ea3n x\u1ea1, m\u1ea5t ph\u1ed1i h\u1ee3p, rung gi\u1eadt c\u01a1, c\u1ee9ng c\u01a1, co gi\u1eadt, nh\u1ecbp tim nhanh, t\u0103ng huy\u1ebft \u00e1p, t\u0103ng th\u00e2n nhi\u1ec7t, v\u00e3 m\u1ed3 h\u00f4i, \u1ea3o gi\u00e1c, k\u00edch \u0111\u1ed9ng ho\u1eb7c b\u1ed3n ch\u1ed3n\u2026)<\/td>\n | 1. C\u1ed1 g\u1eafng tr\u00e1nh s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi linezolid v\u00e0 fentanyl. T\u1ed1t nh\u1ea5t c\u00e1c thu\u1ed1c n\u00e0y n\u00ean s\u1eed d\u1ee5ng c\u00e1ch nhau 2 tu\u1ea7n. C\u00e2n nh\u1eafc thay \u0111\u1ed5i sang c\u00e1c thu\u1ed1c nh\u00f3m kh\u00e1c c\u00f3 c\u00f9ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 \u00edt c\u00f3 nguy c\u01a1 t\u01b0\u01a1ng t\u00e1c h\u01a1n. Trong tr\u01b0\u1eddng h\u1ee3p b\u1eaft bu\u1ed9c s\u1eed d\u1ee5ng opioid, c\u00f3 th\u1ec3 \u0111\u1ed5i sang c\u00e1c opiod kh\u00e1c kh\u00f4ng c\u00f3 ho\u1ea1t t\u00ednh \u1ee9c ch\u1ebf thu h\u1ed3i serotonin (morphin, codein, oxycodon, buprenorphin).<\/p>\n 2. Trong h\u1ee3p kh\u00f4ng th\u1ec3 tr\u00ec ho\u00e3n \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c 2 tu\u1ea7n, b\u1eaft bu\u1ed9c s\u1eed d\u1ee5ng d\u00e0i ng\u00e0y ho\u1eb7c kh\u1ea9n c\u1ea5p b\u1eb1ng linezolid v\u00e0 kh\u00f4ng c\u00f3 thu\u1ed1c kh\u00e1c thay th\u1ebf, c\u00e2n b\u1eb1ng l\u1ee3i \u00edch v\u00e0 nguy c\u01a1 x\u1ea3y ra h\u1ed9i ch\u1ee9ng serotonin. N\u1ebfu l\u1ee3i \u00edch v\u01b0\u1ee3t tr\u1ed9i nguy c\u01a1, v\u1eabn c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi nh\u01b0ng c\u1ea7n gi\u00e1m s\u00e1t ch\u1eb7t ch\u1ebd ch\u1eb7t ch\u1ebd b\u1ec7nh nh\u00e2n, \u0111\u1eb7c bi\u1ec7t trong th\u00e1ng \u0111\u1ea7u ti\u00ean s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi 2 thu\u1ed1c.<\/td>\n<\/tr>\n |
\n| 28<\/td>\n | Nitroglycerin<\/td>\n | Sildenafil<\/td>\n | Hi\u1ec7p \u0111\u1ed3ng t\u0103ng n\u1ed3ng \u0111\u1ed9 guanosine monophosphate (cGMP) v\u00f2ng c\u00f3 d\u1ee5ng gi\u00e3n m\u1ea1ch<\/td>\n | T\u0103ng t\u00e1c d\u1ee5ng h\u1ea1 huy\u1ebft \u00e1p nghi\u00eam tro\u0323ng<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p. N\u1ebfu s\u1eed d\u1ee5ng, hai thu\u1ed1c c\u1ea7n \u0111\u01b0\u1ee3c d\u00f9ng c\u00e1ch nhau \u00edt nh\u1ea5t 24 gi\u1edd<\/td>\n<\/tr>\n |
\n| 29<\/td>\n | Iohexol<\/td>\n | Metformin<\/td>\n | Nguy c\u01a1 suy th\u1eadn c\u1ea5p li\u00ean quan \u0111\u1ebfn c\u1ea3 metformin v\u00e0 thu\u1ed1c c\u1ea3n quang iod. Suy th\u1eadn c\u1ea5p l\u00e0m t\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic.<\/td>\n | T\u0103ng nguy c\u01a1 nhi\u1ec5m toan lactic v\u00e0 suy th\u1eadn c\u1ea5p<\/td>\n | 1. B\u1ec7nh nh\u00e2n c\u00f3 MLCT > 30 ml\/ph\u00fat\/1,73m2<\/sup> v\u00e0 kh\u00f4ng c\u00f3 b\u1eb1ng ch\u1ee9ng t\u1ed5n th\u01b0\u01a1ng th\u1eadn c\u1ea5p, \u0111\u01b0\u1ee3c ch\u1ec9 \u0111\u1ecbnh ti\u00eam thu\u1ed1c c\u1ea3n quang \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch ho\u1eb7c ti\u00eam thu\u1ed1c c\u1ea3n quang \u0111\u01b0\u1eddng \u0111\u1ed9ng m\u1ea1ch ti\u1ebfp x\u00fac v\u1edbi th\u1eadn th\u1ee9 c\u1ea5p (v\u00ed d\u1ee5: b\u01a1m thu\u1ed1c v\u00e0o tim ph\u1ea3i, \u0111\u1ed9ng m\u1ea1ch ph\u1ed5i, \u0111\u1ed9ng m\u1ea1ch c\u1ea3nh, \u0111\u1ed9ng m\u1ea1ch d\u01b0\u1edbi \u0111\u00f2n, \u0111\u1ed9ng m\u1ea1ch v\u00e0nh, \u0111\u1ed9ng m\u1ea1ch m\u1ea1c treo hay \u0111\u1ed9ng m\u1ea1ch d\u01b0\u1edbi \u0111\u1ed9ng m\u1ea1ch th\u1eadn): ti\u1ebfp t\u1ee5c s\u1eed d\u1ee5ng metformin nh\u01b0 b\u00ecnh th\u01b0\u1eddng.<\/p>\n 2. B\u1ec7nh nh\u00e2n (1) MLCT < 30 ml\/ph\u00fat\/1,73m2<\/sup> ti\u00eam thu\u1ed1c c\u1ea3n quang \u0111\u01b0\u1eddng t\u0129nh m\u1ea1ch, \u0111\u01b0\u1eddng \u0111\u1ed9ng m\u1ea1ch ti\u1ebfp x\u00fac v\u1edbi th\u1eadn th\u1ee9 c\u1ea5p, ho\u1eb7c (2) B\u1ec7nh nh\u00e2n ti\u00eam thu\u1ed1c c\u1ea3n quang \u0111\u01b0\u1eddng \u0111\u1ed9ng m\u1ea1ch ti\u1ebfp x\u00fac v\u1edbi th\u1eadn \u0111\u1ea7u ti\u00ean (v\u00ed d\u1ee5: b\u01a1m thu\u1ed1c v\u00e0o tim tr\u00e1i, \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 ng\u1ef1c, \u0111\u1ed9ng m\u1ea1ch ch\u1ee7 b\u1ee5ng tr\u00ean \u0111\u1ed9ng m\u1ea1ch th\u1eadn ho\u1eb7c \u0111\u1ed9ng m\u1ea1ch th\u1eadn) ho\u1eb7c (3) C\u00f3 t\u1ed5n th\u01b0\u01a1ng th\u1eadn: Ng\u1eebng metformin tr\u01b0\u1edbc ho\u1eb7c t\u1ea1i th\u1eddi \u0111i\u1ec3m ti\u1ebfn h\u00e0nh th\u1ee7 thu\u1eadt ch\u1ea9n \u0111o\u00e1n h\u00ecnh \u1ea3nh v\u00e0 kh\u00f4ng \u0111\u01b0\u1ee3c d\u00f9ng l\u1ea1i cho \u0111\u1ebfn \u00edt nh\u1ea5t 48 gi\u1edd sau \u0111\u00f3. Sau 48 gi\u1edd, ch\u1ec9 s\u1eed d\u1ee5ng l\u1ea1i metformin sau khi ch\u1ee9c n\u0103ng th\u1eadn \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 l\u1ea1i v\u00e0 cho th\u1ea5y \u1ed5n \u0111\u1ecbnh.<\/p>\n* L\u01b0u \u00fd:<\/p>\n – C\u00e1c y\u1ebfu t\u1ed1 nguy c\u01a1: suy th\u1eadn, suy tim, kh\u00f4ng \u0111\u1ee7 d\u1ecbch ho\u1eb7c thi\u1ebfu d\u1ecbch, s\u1eed d\u1ee5ng li\u1ec1u cao thu\u1ed1c c\u1ea3n quang ho\u1eb7c s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c \u0111\u1ed9c t\u00ednh tr\u00ean th\u1eadn kh\u00e1c.<\/p>\n – Khuy\u1ebfn c\u00e1o v\u1ec1 t\u01b0\u01a1ng t\u00e1c n\u00e0y kh\u00f4ng \u00e1p d\u1ee5ng trong tr\u01b0\u1eddng h\u1ee3p b\u01a1m thu\u1ed1c c\u1ea3n quang iod \u0111\u1ec3 ch\u1ee5p X-quang t\u1eed cung – v\u00f2i tr\u1ee9ng.<\/td>\n<\/tr>\n \n| 30<\/td>\n | Linezolid<\/td>\n | Methyldopa<\/td>\n | Ch\u01b0a r\u00f5<\/td>\n | T\u0103ng nguy c\u01a1 xu\u1ea5t hi\u1ec7n c\u01a1n t\u0103ng huy\u1ebft \u00e1p (\u0111au \u0111\u1ea7u, \u0111\u00e1nh tr\u1ed1ng ng\u1ef1c, c\u1ee9ng c\u1ed5)<\/td>\n | Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh ph\u1ed1i h\u1ee3p<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u00a0<\/em><\/p>\n\u0110\u00e2y l\u00e0 danh m\u1ee5c t\u1eadp trung v\u00e0o c\u00e1c t\u01b0\u01a1ng t\u00e1c \u1edf m\u1ee9c \u0111\u1ed9 ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh, nh\u00ecn chung kh\u00f4ng khuy\u1ebfn c\u00e1o s\u1eed d\u1ee5ng \u0111\u1ed3ng th\u1eddi c\u00e1c thu\u1ed1c n\u00e0y tr\u00ean b\u1ec7nh nh\u00e2n do nguy c\u01a1 v\u01b0\u1ee3t tr\u1ed9i l\u1ee3i \u00edch thu\u1ed1c c\u00f3 th\u1ec3 \u0111em l\u1ea1i cho b\u1ec7nh nh\u00e2n. Tuy nhi\u00ean, t\u00f9y theo t\u00ecnh hu\u1ed1ng l\u00e2m s\u00e0ng c\u1ee5 th\u1ec3, b\u00e1c s\u0129 c\u00f3 th\u1ec3 tham kh\u1ea3o th\u00f4ng tin v\u00e0 c\u00e2n nh\u1eafc \u0111\u00e1nh gi\u00e1 l\u1ee3i \u00edch\/nguy c\u01a1 tr\u00ean t\u1eebng b\u1ec7nh nh\u00e2n \u0111\u1ec3 \u0111\u01b0a ra quy\u1ebft \u0111\u1ecbnh k\u00ea \u0111\u01a1n ph\u00f9 h\u1ee3p. B\u00ean c\u1ea1nh \u0111\u00f3, Khoa D\u01b0\u1ee3c s\u1ebd ti\u1ebfp t\u1ee5c c\u1eadp nh\u1eadt, b\u1ed5 sung danh m\u1ee5c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh v\u00e0 t\u00edch h\u1ee3p tr\u00ean Ehos khi c\u00f3 thu\u1ed1c m\u1edbi.<\/p>\n T\u00e0i li\u1ec7u tham kh\u1ea3o<\/em><\/strong><\/p>\n\n- Quy\u1ebft \u0111\u1ecbnh 5948\/Q\u0110-BYT v\u1ec1 vi\u1ec7c ban h\u00e0nh danh m\u1ee5c t\u01b0\u01a1ng t\u00e1c thu\u1ed1c ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng t\u1ea1i c\u00e1c c\u01a1 s\u1edf kh\u00e1m b\u1ec7nh, ch\u1eefa b\u1ec7nh.<\/li>\n
- C\u01a1 s\u1edf d\u1eef li\u1ec7u Micromedex, truy c\u1eadp theo \u0111\u01b0\u1eddng d\u1eabn: https:\/\/www.micromedexsolutions.com\/<\/li>\n
- T\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng c\u1ee7a thu\u1ed1c.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
T\u01b0\u01a1ng t\u00e1c thu\u1ed1c l\u00e0 v\u1ea5n \u0111\u1ec1 th\u01b0\u1eddng g\u1eb7p trong th\u1ef1c h\u00e0nh l\u00e2m s\u00e0ng. Trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p t\u01b0\u01a1ng t\u00e1c thu\u1ed1c g\u00e2y ra nh\u1eefng bi\u1ebfn c\u1ed1 b\u1ea5t l\u1ee3i trong \u0111i\u1ec1u tr\u1ecb nh\u01b0 gi\u1ea3m hi\u1ec7u qu\u1ea3 \u0111i\u1ec1u tr\u1ecb, xu\u1ea5t hi\u1ec7n \u0111\u1ed9c t\u00ednh v\u1edbi c\u01a1 th\u1ec3 v\u00e0 c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng c\u1ee7a b\u1ec7nh nh\u00e2n. Nh\u1eb1m h\u1ed7<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1161],"tags":[1174,1176,1172,1175,1173],"class_list":["post-12219","post","type-post","status-publish","format-standard","hentry","category-ban-tin-duoc","tag-an-toan-thuoc","tag-canh-giac-duoc","tag-danh-muc-thuoc","tag-duoc-benh-vien","tag-tuong-tac-chong-chi-dinh"],"_links":{"self":[{"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/posts\/12219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/comments?post=12219"}],"version-history":[{"count":2,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/posts\/12219\/revisions"}],"predecessor-version":[{"id":12235,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/posts\/12219\/revisions\/12235"}],"wp:attachment":[{"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/media?parent=12219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/categories?post=12219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/quoctesannhihaiphong.vn\/en\/wp-json\/wp\/v2\/tags?post=12219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} | |